Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857572 | 0.81 | PTPN1 (0.46) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL9274665 | 0.78 | CASR (0.46) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL12802175 | 0.76 | CASR (0.45) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL10483069 | 0.76 | KCNN4 (0.46) | CYP3A4CYP2D6SLC6A2CA1CA2 | |
| SCHEMBL6846285 | 0.76 | CASR (0.45) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL3984307 | 0.75 | CASR (0.44) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL3983284 | 0.75 | CASR (0.44) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL27508894 | 0.75 | CASR (0.51) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL4069694 | 0.75 | CASR (0.44) | PTPN1CASRCYP3A4CYP2D6SLC6A2 | |
| SCHEMBL599567 | 0.73 | PTPN1 (0.48) | PTPN1CASRCYP3A4CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081274-A1 | MAST CELL-DERIVED RENIN | CORNELL RESEARCH FOUNDATION, INC. (US) | 2009-03-26 | — | — | US | disclosed |
| US-20080032918-A1 | Gene expression or biosynthesis inhibition by locally administering inhibitors of angiotensin-converting enzyme, angiotensin type 1 receptors, or sodium-hydrogen exchange type-1 proteins; antiinflammatory agents, myocardial antiischemic agents, anaphylaxis; sustained release implants, stents, inhalers | CORNELL RESEARCH FOUNDATION, INC. | 2008-02-07 | — | — | US | disclosed |
| US-20050209141-A1 | Mast cell-derived renin | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-09-22 | — | — | US | disclosed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0243477-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| WO-1987002581-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-05-07 | — | — | WO | disclosed |