⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7050994 | 0.79 | — | — | |
| SCHEMBL28573513 | 0.77 | — | — | |
| SCHEMBL6547057 | 0.69 | — | — | |
| SCHEMBL1789455 | 0.69 | — | — | |
| SCHEMBL1558972 | 0.67 | — | — | |
| SCHEMBL1559428 | 0.67 | — | — | |
| SCHEMBL1558975 | 0.67 | — | — | |
| SCHEMBL1059969 | 0.67 | — | — | |
| SCHEMBL456363 | 0.67 | TSHR (0.42) | — | |
| SCHEMBL4868038 | 0.65 | TSHR (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250389728-A1 | NOVEL CLASS OF TRIOXANE-BASED MS-CLEAVABLE CROSS-LINKERS TO ADVANCE PROTEIN-PROTEIN INTERACTION STUDIES USING CROSS-LINKING MASS SPECTROMETRY | UNIV CALIFORNIA (US) | 2025-12-25 | — | — | US | disclosed |
| EP-1461340-B1 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LTD (GB) | 2009-04-08 | — | — | EP | disclosed |
| US-20050070595-A1 | Trioxane derivatives as antimalaria or anticancer compounds | UFC LIMITED (GB) | 2005-03-31 | — | — | US | disclosed |
| EP-1461340-A2 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LIMITED (GB) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003048168-A2 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| US-RE38117-E1 | Trioxane dimer compound having antiproliferative and antitumor activities | HAUSER, INC. | 2003-05-06 | — | — | US | disclosed |
| US-6486362-B1 | Process for producing oxygen-containing compounds containing at least one oxygen atom bonded to two distinct carbon atoms which are not bonded together and not including a multiple bond | INSTITUT FRANCAIS DU PETROLE (FR) | 2002-11-26 | — | — | US | disclosed |
| EP-1021438-A4 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | HAUSER INC (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1021438-A1 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | Hauser, Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| US-6004997-A | ANTICANCER AGENTS | HAUSER, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| US-5840925-A | Trioxane dimer compounds having antiproliferative and antitumor activities | HAUSER, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1998024786-A9 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | — | 1998-10-08 | — | — | WO | disclosed |
| WO-1998024786-A1 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | HAUSER, INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| EP-0585080-A2 | Oxygenated heterocyclic compounds, pharmaceutical compositions containing them | OXACO S.A. (CH) | 1994-03-02 | — | — | EP | disclosed |
| WO-1993014756-A1 | 1,2,4-TRIOXANE COMPOUNDS HAVING ANTIMALARIAL ACTIVITY | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5225437-A | 1,2,4-trioxane compounds having antimalarial activity | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-07-06 | — | — | US | disclosed |