Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.41 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376377 | 0.91 | F10 (0.74) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5781417 | 0.90 | F10 (0.65) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5777469 | 0.87 | F10 (0.74) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5779422 | 0.87 | F10 (0.73) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5779855 | 0.87 | F10 (0.73) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5784059 | 0.86 | F10 (0.72) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL3984298 | 0.86 | F10 (0.63) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5782623 | 0.85 | F10 (0.76) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5783650 | 0.85 | F10 (0.69) | F10HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5782214 | 0.84 | F10 (0.70) | F10HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029582-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007137790-A1 | ISOINDOLIN-1-ONE-, ISOINDOLIN-3-ONE- AND ISOINDOLIN-1,3-DIONE-DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2007-12-06 | — | — | WO | disclosed |