Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DPYD | Q12882 | 1/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281216 | 0.84 | PTGDR2 (0.49) | PTGDR2FFAR1LMNADPYDPTGIR | |
| SCHEMBL4268589 | 0.83 | PTGDR2 (0.58) | PTGDR2LMNADPYDPTGIR | |
| SCHEMBL4270241 | 0.80 | PTGDR2 (0.46) | PTGDR2FFAR1DPYDPTGIR | |
| SCHEMBL4276635 | 0.78 | SNCA (0.45) | PTGDR2KMT2ANPC1LMNA | |
| SCHEMBL8358555 | 0.76 | KMT2A (0.64) | HPGDKMT2AFFAR1NPC1LMNA | |
| SCHEMBL3175595 | 0.75 | PTGDR2 (0.68) | PTGDR2HPGDKMT2AFFAR1NPC1 | |
| SCHEMBL4274009 | 0.74 | PTGDR2 (0.55) | PTGDR2FFAR1PTGIR | |
| SCHEMBL4270407 | 0.73 | PTGDR2 (0.41) | PTGDR2FFAR1NPC1PTGIR | |
| SCHEMBL8356709 | 0.72 | TACR1 (0.55) | PTGDR2HPGDKMT2AFFAR1LMNA | |
| SCHEMBL8804316 | 0.71 | CNR1 (0.65) | PTGDR2KMT2AFFAR1PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |