Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIKFYVE | Q9Y2I7 | 3/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 11/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.35 |
| ▸ | TSSK3 | Q96PN8 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | TSSK1B | Q9BXA7 | 1/20 | 0.35 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.35 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.35 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.35 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425767 | 0.94 | MAPKAPK2 (0.37) | PIKFYVEMAPKAPK2 | |
| SCHEMBL429912 | 0.88 | MAPKAPK2 (0.40) | MAPKAPK2 | |
| SCHEMBL428594 | 0.84 | MAPKAPK2 (0.37) | MAPKAPK2 | |
| SCHEMBL431557 | 0.84 | MAPKAPK2 (0.44) | MAPKAPK2MAPT | |
| SCHEMBL428126 | 0.83 | MAPKAPK2 (0.54) | MAPKAPK2 | |
| SCHEMBL424662 | 0.83 | MAPKAPK2 (0.39) | MAPKAPK2 | |
| SCHEMBL426535 | 0.82 | MAPKAPK2 (0.37) | MAPKAPK2 | |
| SCHEMBL428122 | 0.82 | MAPKAPK2 (0.38) | MAPKAPK2 | |
| SCHEMBL426979 | 0.82 | MAPKAPK2 (0.36) | PIKFYVEMAPKAPK2PAK4PRKXTTBK1 | |
| SCHEMBL428414 | 0.81 | MAPKAPK2 (0.47) | MAPKAPK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2012-01-26 | — | — | US | disclosed |
| US-7838674-B2 | 2-(1-amino-cyclobutylmethyl)-8-(4-methoxy-phenyl)-4,5-dihydro-1 H-1,7,9-triazacyclopenta[a]naph-thalene-3-carboxylic acid lactame; useful especially as inhibitors of mitogen-activated protein kinase-activated protein kinase-2 (MK2 or MAPKAP kinase-2 | NOVARTIS AG (CH) | 2010-11-23 | — | — | US | disclosed |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | NOVARTIS AG | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022030-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | PIKFYVE 1254/4885MAPKAPK2 480/4885PAK4 1972/4885 |
| US-20090098218-A1 | Tetracyclic Lactame Derivatives | TNF, RPS6KB2, RPS6KA2 | PIKFYVE 1254/4885MAPKAPK2 480/4885PAK4 1972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.