Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 17/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 12/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362777 | 0.79 | — | — | |
| SCHEMBL10178067 | 0.79 | — | — | |
| SCHEMBL3415496 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL28769763 | 0.77 | S1PR5 (0.47) | S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL884034 | 0.77 | S1PR5 (0.42) | S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL884032 | 0.77 | S1PR5 (0.42) | S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL4678458 | 0.75 | PLG (0.45) | S1PR5S1PR1PLGPLATLMNA | |
| SCHEMBL19897423 | 0.75 | S1PR5 (0.41) | S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL1362081 | 0.75 | S1PR5 (0.41) | S1PR5S1PR1S1PR3S1PR4 | |
| SCHEMBL11917621 | 0.75 | SMN1; SMN2 (0.51) | S1PR5S1PR1S1PR3S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7605269-B2 | Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-10-20 | — | — | US | claimed |