Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CCR9 | P51686 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29872776 | 0.91 | NPC1 (0.39) | NPC1MAPTF11DGAT1SLC22A12 | |
| SCHEMBL2200166 | 0.87 | NPC1 (0.37) | NPC1MAPTKMT2A | |
| SCHEMBL29284097 | 0.83 | NPC1 (0.41) | NPC1MAPTKLKB1F11CCR9 | |
| SCHEMBL18975873 | 0.83 | NPC1 (0.36) | NPC1MAPTMEN1NR2F2KMT2A | |
| SCHEMBL29538442 | 0.82 | NPC1 (0.35) | NPC1MAPTDGAT1MEN1NR2F2 | |
| SCHEMBL30893392 | 0.82 | NPC1 (0.35) | NPC1MAPTDGAT1MEN1NR2F2 | |
| SCHEMBL21484366 | 0.82 | NPC1 (0.35) | NPC1MAPTDGAT1MEN1NR2F2 | |
| SCHEMBL15218164 | 0.82 | NPC1 (0.35) | NPC1MAPTDGAT1MEN1NR2F2 | |
| SCHEMBL29452528 | 0.81 | NPC1 (0.35) | NPC1MAPTMEN1NR2F2KMT2A | |
| SCHEMBL13826482 | 0.81 | NPC1 (0.35) | NPC1MAPTMEN1NR2F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773826-A4 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-1773826-A2 | C-MET MODULATORS AND METHOD OF USE | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014325-A2 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |