SCHEMBL4270686

SCHEMBL4270686

Brc1cncc(-c2cccnc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 7/20 0.62
ALDH1A1 P00352 2/20 0.62
CYP3A4 P08684 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP11B1 P15538 4/20 0.58
CYP11B2 P19099 4/20 0.58
MKNK1 Q9BUB5 2/20 0.50
MKNK2 Q9HBH9 2/20 0.50
MEN1 O00255 1/20 0.50
PSIP1 O75475 1/20 0.50
AXL P30530 1/20 0.50
CYP19A1 P11511 2/20 0.48
DYRK1A Q13627 1/20 0.48
DYRK1B Q9Y463 1/20 0.48
CYP17A1 P05093 1/20 0.48
KDM4E B2RXH2 1/20 0.48
LMNA P02545 1/20 0.48
TP53 P04637 1/20 0.48
MAPT P10636 1/20 0.48
HPGD P15428 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30335566 1.00 CYP2A6 (0.62) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL12576018 0.94 CYP11B1 (0.57) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL21311982 0.93 CYP11B1 (0.56) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL12129641 0.93 CYP11B1 (0.56) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL13244061 0.85 CYP2A6 (0.65) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL9656595 0.85 CYP2A6 (0.65) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL30687563 0.85 CYP2A6 (0.65) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL21312051 0.85 CYP2A6 (0.65) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL30398823 0.85 CYP2A6 (0.65) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1
SCHEMBL1935147 0.85 CYP11B1 (0.49) CYP2A6ALDH1A1CYP3A4CYP1A2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108912154-B Base material for preparing bipolar electroluminescent material 大连理工大学 2021-04-16 CN claimed
CN-108752372-B Compound for preparing organic electroluminescent material 大连理工大学 2021-01-22 CN claimed
CN-111606887-B Novel kinase inhibitor 安徽中科拓苒药物科学研究有限公司 2023-03-17 CN disclosed
CN-108912154-B Base material for preparing bipolar electroluminescent material 大连理工大学 2021-04-16 CN disclosed
CN-109053690-B Bipolar electroluminescent material containing carbazole group and application thereof 大连理工大学 2021-04-16 CN disclosed
CN-108752372-B Compound for preparing organic electroluminescent material 大连理工大学 2021-01-22 CN disclosed
CN-111606887-A Novel kinase inhibitor 安徽中科拓苒药物科学研究有限公司 2020-09-01 CN disclosed
US-20190312213-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND APPLICATION THEREOF DALIAN UNIVERSITY OF TECHNOLOGY (CN) 2019-10-10 US disclosed
US-9379336-B2 Compounds for use in light emitting devices NITTO DENKO CORPORATION (JP) 2016-06-28 US disclosed
US-9379336-B2 Compounds for use in light emitting devices NITTO DENKO CORPORATION (JP) 2016-06-28 US disclosed
US-9379336-B2 Compounds for use in light emitting devices NITTO DENKO CORPORATION (JP) 2016-06-28 US disclosed
US-7365174-B2 Azalide and azalactam derivatives and method for producing the same MEIJI SEIKA KAISHA, LTD. (JP) 2008-04-29 US disclosed
CN-100343237-C Amide derivative and medicine NIPPON SHINYAKU CO LTD (JP) 2007-10-17 CN disclosed
US-20070042974-A1 Nozel azalide and azalactam derivatives and method for producing the same MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-22 US disclosed
EP-1661904-A1 NOVEL AZALIDE AND AZALACTAM DERIVATIVES AND PROCESS FOR THE PRODUCTION OF THE SAME MEIJI SEIKA KAISHA LTD. (JP) 2006-05-31 EP disclosed
US-20060014742-A1 Amide derivative NIPPON SHINYAKU CO., LTD. (JP) 2006-01-19 US disclosed
CN-1678590-A Amide derivative and pharmaceutical NIPPON SHINYAKU CO LTD (JP) 2005-10-05 CN disclosed
EP-1533304-A1 AMIDE DERIVATIVE Nippon Shinyaku Co., Ltd. (JP) 2005-05-25 EP disclosed
US-5409920-A 2-(3-pyridyl)-carbapenem antibacterial agents MERCK & CO., INC. (US) 1995-04-25 US disclosed
EP-0479574-A2 2-(3-pyridyl)-carbapenem antibacterial agents MERCK & CO. INC. (US) 1992-04-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014742-A1 Amide derivative ABL1, ABL2, BCR CYP2A6 239/4885ALDH1A1 753/4885CYP3A4 1045/4885
US-20070042974-A1 Nozel azalide and azalactam derivatives and method for producing the same BCL6, NR4A1, NR4A2 CYP2A6 23/4885ALDH1A1 1363/4885CYP3A4 297/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.