Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280987 | 0.86 | NPC1 (0.41) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4275542 | 0.80 | POLB (0.36) | POLBHPGDL3MBTL1THRBRECQL | |
| SCHEMBL753818 | 0.74 | HPGD (0.47) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL754735 | 0.69 | SMN1; SMN2 (0.43) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4272854 | 0.69 | POLB (0.36) | POLBSMN1; SMN2APLNRRECQLTMEM97 | |
| SCHEMBL13255439 | 0.69 | HPGD (0.44) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13255465 | 0.69 | HPGD (0.50) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4279016 | 0.68 | POLB (0.38) | POLBHPGDSMN1; SMN2THRBRECQL | |
| SCHEMBL13255481 | 0.68 | SMN1; SMN2 (0.47) | POLBHPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12020187 | 0.68 | HPGD (0.47) | POLBHPGDSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312335-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-12-17 | — | — | US | disclosed |
| US-20090312335-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-12-17 | — | — | US | disclosed |
| US-20090312335-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2009-12-17 | — | — | US | disclosed |
| WO-2007050510-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312335-A1 | Hiv Integrase Inhibitors | RECQL, TYMP, POLR2H | POLB 19/4885HPGD 460/4885SMN1; SMN2 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.