Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 19/20 | 0.86 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.86 |
| ▸ | YES1 | P07947 | 2/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4265035 | 0.93 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4272991 | 0.88 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL15682983 | 0.84 | SRC (0.87) | SRCPDGFRBYES1KDREPHB4 | |
| Trifluoroacetic Acid SCHEMBL15663224 | 0.82 | SRC (0.58) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4265970 | 0.82 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4264644 | 0.81 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4272211 | 0.81 | SRC (0.83) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4269606 | 0.79 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL4273719 | 0.79 | SRC (1.00) | SRCPDGFRBYES1KDREPHB4 | |
| SCHEMBL15095264 | 0.78 | SRC (0.84) | SRCPDGFRBYES1KDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809614-B1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN INC (US) | 2014-05-07 | — | — | EP | disclosed |
| US-8481536-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2543376-A1 | Benzotriazine inhibitors of kinases | Targegen, Inc. (US) | 2013-01-09 | — | — | EP | disclosed |
| US-20110294796-A1 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20090275569-A1 | Benzotriazine Inhibitors of Kinases | TARGEGEN, INC. | 2009-11-05 | — | — | US | disclosed |
| US-7456176-B2 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20050245524-A1 | Benzotriazine inhibitors of kinases | TARGEGEN, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294796-A1 | BENZOTRIAZINE INHIBITORS OF KINASES | SRC, CAMK4, CAMK2G | SRC 1/4885PDGFRB 221/4885YES1 237/4885 |
| US-20090275569-A1 | Benzotriazine Inhibitors of Kinases | SRC, CAMK4, CAMK2G | SRC 1/4885PDGFRB 221/4885YES1 237/4885 |
| US-20050245524-A1 | Benzotriazine inhibitors of kinases | SRC, CAMK4, CAMK2G | SRC 1/4885PDGFRB 221/4885YES1 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.