Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 17/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 17/20 | 0.65 |
| ▸ | CDC7 | O00311 | 15/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 14/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4563578 | 1.00 | PIM1 (0.65) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4280461 | 0.87 | PIM1 (0.62) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850649 | 0.85 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852448 | 0.85 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850651 | 0.85 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4277139 | 0.83 | PIM1 (0.56) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1853925 | 0.79 | CSNK2B (1.00) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852676 | 0.79 | CSNK2B (1.00) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL4287795 | 0.76 | PIM1 (0.55) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1851020 | 0.75 | PIM1 (0.59) | PIM1CSNK2BCDC7CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |