Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.88 |
| ▸ | LCK | P06239 | 1/20 | 0.88 |
| ▸ | FYN | P06241 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL9118003 | 1.00 | — | — | |
| Acetic Acid SCHEMBL15348726 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL4655827 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL9120240 | 1.00 | — | — | |
| Acetic Acid SCHEMBL49684 | 1.00 | — | — | |
| Acetic Acid SCHEMBL8382903 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL5578924 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL9118178 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL6383246 | 1.00 | FFAR3 (0.88) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL3447882 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118703598-A | Label-free fluorescence detection system for detecting cleavage-connection activity of topoisomerase I and application thereof | 青岛科技大学 | 2024-09-27 | — | — | CN | claimed |
| CN-118703598-A | Label-free fluorescence detection system for detecting cleavage-connection activity of topoisomerase I and application thereof | 青岛科技大学 | 2024-09-27 | — | — | CN | disclosed |
| CN-113816845-B | Process for preparing trifluoroacetic acid | 常熟三爱富中昊化工新材料有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-111032648-B | Organic triazine-containing molecules, in particular for optoelectronic devices | 三星显示有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-216440607-U | Reaction system for producing solid-liquid chemical reaction | 常熟三爱富中昊化工新材料有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-113816845-A | Preparation method of trifluoroacetic acid | 常熟三爱富中昊化工新材料有限公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-107849449-B | Substituted benzotriazole phenolates and antioxidant compositions formed therefrom | 3M创新有限公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-111032648-A | Organic triazine-containing molecules, in particular for optoelectronic devices | 辛诺拉有限公司 | 2020-04-17 | — | — | CN | disclosed |
| US-20120220962-A1 | TRANSDERMAL AND TOPICAL ADMINISTRATION OF VITAMINS USING BASIC PERMEATION ENHANCERS | TECHNOLOGY RECOVERY SYSTEMS, LLC (US) | 2012-08-30 | — | — | US | disclosed |
| US-20090317453-A1 | TRANSDERMAL AND TOPICAL ADMINISTRATION OF DRUGS USING BASIC PERMEATION ENHANCERS | DERMATRENDS, INC. (US) | 2009-12-24 | — | — | US | disclosed |
| US-20090197849-A1 | TRANSDERMAL AND TOPICAL ADMINISTRATION OF DRUGS USING BASIC PERMEATION ENHANCERS | DERMATRENDS, INC. | 2009-08-06 | — | — | US | disclosed |
| US-20070098747-A1 | Topical pharmaceutical composition for the treatment of inflammatory dermatoses | DERMATRENDS, INC. | 2007-05-03 | — | — | US | disclosed |
| US-7205003-B2 | Method and topical formulation for treating skin conditions associated with aging | DERMATRENDS, INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20060002874-A1 | Topical pharmaceutical composition to treat hyperpigmentation of the skin | DERMATRENDS, INC. | 2006-01-05 | — | — | US | disclosed |
| US-6943197-B2 | Topical administration of pharmacologically active bases in the treatment of inflammatory dermatoses | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2005-09-13 | — | — | US | disclosed |
| US-20050074487-A1 | Transdermal and topical administration of drugs using basic permeation enhancers | DERMATRENDS, INC. | 2005-04-07 | — | — | US | disclosed |
| US-6846837-B2 | Topical administration of basic antifungal compositions to treat fungal infections of the nails | TECHNOLOGY RECOVERY SYSTEMS, LLC | 2005-01-25 | — | — | US | disclosed |
| US-6821523-B2 | APPLYING BASIC DRUGS TO SKINS FOR PROPHYLAXIS OF HUMAN PAPILLOMAVIRUS INFECTIONS; SKIN DISODERS | DERMATRENDS, INC. | 2004-11-23 | — | — | US | disclosed |
| US-6673363-B2 | Transdermal and topical administration of local anesthetic agents using basic enhancers | DERMATRENDS, INC. | 2004-01-06 | — | — | US | disclosed |
| WO-2004000249-A1 | TOPICAL PHARMACEUTICAL COMPOSITION TO TREAT HYPERPIGMENTATION OF THE SKIN | DERMATRENDS, INC. (US) | 2003-12-31 | — | — | WO | disclosed |