Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 11/20 | 0.75 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27866949 | 0.97 | PTGDR2 (0.70) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL4275259 | 0.90 | PTGDR2 (0.77) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL27866948 | 0.87 | PTGDR2 (0.72) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL3168930 | 0.85 | PTGDR2 (1.00) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL3165304 | 0.85 | PTGDR2 (1.00) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL3168945 | 0.85 | PTGDR2 (1.00) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL3174445 | 0.85 | PTGDR2 (1.00) | PTGDR2PTGDRSIGMAR1HDAC3HDAC4 | |
| SCHEMBL27866951 | 0.85 | PTGDR2 (0.55) | PTGDR2PTGDR | |
| SCHEMBL3159628 | 0.84 | PTGDR2 (1.00) | PTGDR2PTGDRPTGIR | |
| SCHEMBL3168938 | 0.83 | PTGDR2 (0.73) | PTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |