Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 16/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27792973 | 0.87 | CHRM3 (0.46) | CHRM3 | |
| SCHEMBL2126693 | 0.82 | CHRM3 (0.61) | CHRM3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4738397 | 0.76 | CHRM3 (0.77) | CHRM3 | |
| SCHEMBL2127676 | 0.76 | CYP2B6 (0.59) | CHRM3CYP2B6 | |
| SCHEMBL4444477 | 0.76 | CYP2B6 (0.59) | CHRM3CYP2B6 | |
| SCHEMBL3043721 | 0.76 | CYP2B6 (0.59) | CHRM3CYP2B6 | |
| SCHEMBL2126740 | 0.76 | CYP2B6 (0.59) | CHRM3CYP2B6 | |
| SCHEMBL3309137 | 0.74 | CHRM3 (0.44) | CHRM3GAACYP2B6MEN1KMT2A | |
| SCHEMBL7592805 | 0.74 | CHRM3 (0.57) | CHRM3GAACYP2B6SMN1; SMN2 | |
| SCHEMBL11019030 | 0.74 | CHRM3 (0.43) | CHRM3GAACYP2B6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121137-B1 | QUINUCLIDINOL DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2012-04-25 | — | — | EP | disclosed |
| WO-2009153536-A1 | 1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009153536-A1 | 1-AZA-BICYCLO [2.2.2] OCTANE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | ARGENTA DISCOVERY LIMITED (GB) | 2009-12-23 | — | — | WO | disclosed |
| CN-101610813-A | Quinuclidinol derivatives as muscarinic receptor antagonist | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | CN | disclosed |
| WO-2008075005-A1 | QUINUCLIDINOL DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |