Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2B | P67870 | 20/20 | 0.64 |
| ▸ | PIM1 | P11309 | 19/20 | 0.64 |
| ▸ | CDC7 | O00311 | 9/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 13/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 12/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 12/20 | 0.60 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12661564 | 0.83 | CSNK2B (0.67) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1856877 | 0.83 | CSNK2B (0.67) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1853268 | 0.81 | CSNK2B (0.67) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1854454 | 0.80 | CSNK2B (0.69) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1857243 | 0.80 | CSNK2B (0.63) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1850855 | 0.80 | PIM1 (0.69) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1852949 | 0.79 | CSNK2B (0.58) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1853281 | 0.78 | CSNK2B (1.00) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1854480 | 0.78 | CSNK2B (1.00) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 | |
| SCHEMBL1849054 | 0.78 | CSNK2B (1.00) | CSNK2BPIM1CDC7CSNK2A1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |