Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Myrtenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | CXCR3 | P49682 | 16/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Myrtenol SCHEMBL4826734 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL820534 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL15536292 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL155709 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL14763830 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL24281940 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL3836506 | 0.96 | TSHR (0.58) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL15442582 | 0.90 | KCNH2 (0.52) | TSHRKDM4EHTTTDP1MAPK1 | |
| Myrtenol SCHEMBL4281808 | 0.88 | TSHR (0.51) | TSHRKDM4EHTTTDP1MAPK1 | |
| Nopol SCHEMBL2302936 | 0.86 | KCNH2 (0.55) | TSHRKDM4EHTTTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090031455-A1 | TERPENE HYDROXYLATION | PLANT RESEARCH INTERNATIONAL B.V. (NL) | 2009-01-29 | — | — | US | disclosed |
| EP-1805311-A2 | TERPENE HYDROXYLATION | Plant Research International B.V. (NL) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006065126-A2 | TERPENE HYDROXYLATION | PLANT RESEARCH INTERNATIONAL B.V. (NL) | 2006-06-22 | — | — | WO | disclosed |