SCHEMBL4278129

SCHEMBL4278129

Cc1nc(Cl)c(-c2nc(-c3cc(O)c(O)c([N+](=O)[O-])c3)cs2)c(C)c1C.O=[N+]([O-])c1cc(-c2csc(-c3cccnc3C(F)(F)F)n2)cc(O)c1O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EIF4E P06730 19/20 0.39
GFER P55789 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3580015 0.88 EIF4E (0.47) EIF4EGFER
SCHEMBL3586799 0.86 COMT (0.42) EIF4E
SCHEMBL3587040 0.80 COMT (0.46) EIF4E
SCHEMBL3589876 0.76 EIF4E (0.47) EIF4E
SCHEMBL3577466 0.75 COMT (0.40) EIF4E
SCHEMBL3576471 0.74 EIF4E (0.46) EIF4EGFER
SCHEMBL3578955 0.73 COMT (0.40) EIF4E
SCHEMBL3589608 0.73 COMT (0.44)
SCHEMBL3595074 0.73 MAPT (0.44) GFER
SCHEMBL3587824 0.73 EIF4E (0.39) EIF4EGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2027091-A1 NEW PHARMACEUTICAL COMPOUNDS BIAL - Portela & Ca., S.A. (PT) 2009-02-25 EP disclosed
WO-2007117165-A1 NEW PHARMACEUTICAL COMPOUNDS BIAL - PORTELA & CA, S.A. (PT) 2007-10-18 WO disclosed