Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.61 |
| ▸ | CSNK2B | P67870 | 18/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 17/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 17/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 17/20 | 0.57 |
| ▸ | CDC7 | O00311 | 2/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106799 | 0.91 | PIM1 (0.58) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1852809 | 0.88 | PIM1 (0.78) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1853175 | 0.88 | PIM1 (0.50) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1854679 | 0.80 | PIM1 (0.81) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1853349 | 0.76 | PIM1 (1.00) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1849042 | 0.75 | CSNK2B (0.76) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1851908 | 0.75 | CSNK2A2 (0.76) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1849861 | 0.74 | CSNK2A2 (1.00) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL12660742 | 0.73 | CSNK2B (0.74) | PIM1CSNK2BCSNK2A2PIM3PIM2 | |
| SCHEMBL1858382 | 0.73 | PIM1 (0.91) | PIM1CSNK2BCSNK2A2PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | claimed |