Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 13/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.57 |
| ▸ | ABL1 | P00519 | 4/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.57 |
| ▸ | BCR | P11274 | 3/20 | 0.57 |
| ▸ | FLT3 | P36888 | 3/20 | 0.57 |
| ▸ | PLK4 | O00444 | 2/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.57 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | FES | P07332 | 2/20 | 0.57 |
| ▸ | LYN | P07948 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282755 | 0.91 | IGF1R (0.69) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4281352 | 0.91 | IGF1R (0.69) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4279931 | 0.90 | IGF1R (0.65) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4278041 | 0.90 | IGF1R (0.65) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4281984 | 0.90 | IGF1R (0.76) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4282057 | 0.90 | IGF1R (0.68) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL2915850 | 0.90 | IGF1R (0.70) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4285181 | 0.88 | IGF1R (0.69) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4285399 | 0.87 | IGF1R (0.65) | IGF1RAURKAAURKBABL1FGFR1 | |
| SCHEMBL4278012 | 0.87 | CCNA2 (0.63) | IGF1RAURKACDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136513-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2009-05-28 | — | — | US | claimed |
| US-9012487-B2 | Bicyclo-pyrazoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-04-21 | — | — | US | disclosed |
| US-20090136513-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136513-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS | MAP3K19, CDK2, MAP3K1 | IGF1R 530/4885AURKA 42/4885AURKB 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.