Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | MECP2 | P51608 | 1/20 | 0.33 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287050 | 0.74 | AGPAT2 (0.33) | CYP1A2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL4282527 | 0.71 | HSP90AA1 (0.34) | CYP1A2LMNAKDM4EHPGDMAPT | |
| SCHEMBL4284234 | 0.68 | AGPAT2 (0.34) | CYP1A2KDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL4280081 | 0.68 | CYP1A2 (0.37) | CYP1A2LMNAKDM4ESMN1; SMN2KDM1A | |
| SCHEMBL2323806 | 0.67 | CYP1A2 (0.36) | CYP1A2LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL10833965 | 0.59 | CYP1A2 (0.81) | CYP1A2LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL27859632 | 0.59 | CYP1A2 (0.93) | CYP1A2LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| 1,4-Dichlorobenzene SCHEMBL9297848 | 0.59 | TSHR (0.92) | CYP1A2LMNAKDM4EMAPTGAA | |
| SCHEMBL183912 | 0.57 | CYP1A2 (1.00) | CYP1A2LMNAKDM4ESMN1; SMN2ALDH1A1 | |
| Biphenyl SCHEMBL27505710 | 0.57 | CYP1A2 (0.77) | CYP1A2LMNAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | CYP1A2 4325/4885LMNA 1834/4885KDM4E 1842/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | CYP1A2 4519/4885LMNA 1671/4885KDM4E 2160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.