Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.37 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4281919 | 0.90 | PTGDR2 (0.52) | PTGDR2MAPTALDH1A1SMN1; SMN2CASR | |
| SCHEMBL4273938 | 0.88 | PTGDR2 (0.61) | PTGDR2MAPTALDH1A1SMN1; SMN2CASR | |
| SCHEMBL3174421 | 0.87 | PTGDR2 (0.72) | PTGDR2LMNAPTGIRBCHE | |
| SCHEMBL3174429 | 0.87 | PTGDR2 (0.72) | PTGDR2LMNAPTGIRBCHE | |
| SCHEMBL4267926 | 0.86 | PTGDR2 (0.49) | PTGDR2MAPTALDH1A1SMN1; SMN2CASR | |
| SCHEMBL3166266 | 0.85 | PTGDR2 (0.52) | PTGDR2 | |
| SCHEMBL3166279 | 0.85 | PTGDR2 (0.52) | PTGDR2 | |
| SCHEMBL4272587 | 0.85 | PTGDR2 (0.74) | PTGDR2MAPTALDH1A1SMN1; SMN2CASR | |
| SCHEMBL12678754 | 0.83 | PTGDR2 (0.58) | PTGDR2FDFT1HPGDPTGIRBCHE | |
| SCHEMBL4272486 | 0.81 | PTGDR2 (0.66) | PTGDR2MAPTALDH1A1SMN1; SMN2CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |