SCHEMBL4282116

SCHEMBL4282116

CC(C)(C)OC(=O)Nc1ccc(-c2ccsc2)cc1NC(=O)c1ccc(N)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 11/20 0.54
HDAC2 Q92769 5/20 0.47
CHEK2 O96017 1/20 0.41
HDAC3 O15379 2/20 0.40
KCNH2 Q12809 2/20 0.40
CYP17A1 P05093 1/20 0.40
MAP3K5 Q99683 1/20 0.40
P2RY14 Q15391 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
MAPK1 P28482 1/20 0.40
HDAC4 P56524 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39
HDAC5 Q9UQL6 1/20 0.39
WDR5 P61964 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4282110 0.90 HDAC1 (0.49) HDAC1HDAC2CHEK2HDAC3KCNH2
SCHEMBL10121375 0.84 HDAC1 (0.49) HDAC1HDAC2HDAC3KCNH2CYP17A1
SCHEMBL651518 0.84 HDAC1 (0.52) HDAC1HDAC2HDAC3KCNH2CYP17A1
SCHEMBL8172813 0.84 HDAC1 (0.46) HDAC1HDAC2KCNH2CYP17A1MAPT
SCHEMBL1705492 0.84 HDAC1 (0.51) HDAC1HDAC2HDAC3CYP17A1GAA
SCHEMBL4126494 0.83 HDAC1 (0.58) HDAC1HDAC2CHEK2HDAC3KCNH2
SCHEMBL650774 0.83 HDAC1 (0.59) HDAC1HDAC2HDAC3KCNH2HDAC4
SCHEMBL30091854 0.83 HDAC1 (0.59) HDAC1HDAC2HDAC3KCNH2HDAC4
SCHEMBL15856234 0.83 MAPT (0.52) HDAC1CYP17A1GAAMAPTMAPK1
SCHEMBL25244303 0.83 HDAC1 (0.43) HDAC1HDAC2HDAC3KCNH2CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2013196-A2 DISUBSTITUTED ANILINE COMPOUNDS Merck & Co., Inc. (US) 2009-01-14 EP disclosed
WO-2007127137-A2 DISUBSTITUTED ANILINE COMPOUNDS MERCK & CO., INC. (US) 2007-11-08 WO disclosed