Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3506358 | 0.91 | FGFR1 (0.39) | EGFRERBB2ERBB3ERBB4SMN1; SMN2 | |
| SCHEMBL2748396 | 0.86 | FGFR1 (0.37) | EGFRERBB2ERBB3ERBB4SMN1; SMN2 | |
| SCHEMBL7028699 | 0.80 | FGFR1 (0.35) | SMN1; SMN2LMNAFGFR1FGFR4MAPT | |
| SCHEMBL2749135 | 0.79 | FGFR1 (0.40) | EGFRERBB2ERBB3ERBB4FGFR1 | |
| SCHEMBL27664616 | 0.78 | TLR8 (0.44) | SMN1; SMN2LMNAFGFR1FGFR4GRIN2B | |
| SCHEMBL3403862 | 0.77 | FGFR1 (0.40) | EGFRERBB2ERBB3ERBB4FGFR1 | |
| SCHEMBL2748299 | 0.77 | TDP1 (0.40) | EGFRERBB2ERBB3ERBB4SMN1; SMN2 | |
| SCHEMBL2748523 | 0.76 | FGFR1 (0.42) | EGFRERBB2ERBB3ERBB4FGFR1 | |
| SCHEMBL2748776 | 0.76 | FGFR1 (0.40) | EGFRERBB2ERBB3ERBB4FGFR1 | |
| SCHEMBL2749352 | 0.76 | EGFR (0.44) | EGFRERBB2ERBB3ERBB4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137580-A1 | Fused Heterocyclic Derivatives and Use Thereof | TIE1, KDR, FLT1 | EGFR 20/4885ERBB2 8/4885ERBB3 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.