Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4325777 | 0.91 | NR1H4 (0.67) | NR1H4 | |
| SCHEMBL4275550 | 0.90 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL4280055 | 0.90 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL2128933 | 0.88 | NR1H4 (0.87) | NR1H4 | |
| SCHEMBL4327129 | 0.86 | NR1H4 (0.87) | NR1H4 | |
| SCHEMBL19629742 | 0.83 | NR1H4 (0.64) | NR1H4 | |
| SCHEMBL29416534 | 0.82 | NR1H4 (0.79) | NR1H4 | |
| SCHEMBL2130307 | 0.81 | NR1H4 (1.00) | NR1H4 | |
| SCHEMBL12188526 | 0.81 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL4282532 | 0.81 | NR1H4 (0.87) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009149795-A2 | HETEROCYCLIC CYCLOPROPYL-SUBSTITUTED FXR BINDING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2009-12-17 | — | — | WO | disclosed |
| EP-2128158-A1 | Heterocyclic cyclopropyl-substituted FXR binding compounds | Phenex Pharmaceuticals AG (DE) | 2009-12-02 | — | — | EP | disclosed |