Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196749 | 0.97 | CHRM2 (0.89) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL24770601 | 0.97 | CHRM2 (0.89) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL2399328 | 0.94 | CHRM2 (0.94) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL5603309 | 0.94 | CHRM2 (0.94) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL11434663 | 0.91 | CHRM2 (0.68) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL2400821 | 0.91 | CHRM2 (0.88) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL17428467 | 0.91 | CHRM2 (1.00) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL6755328 | 0.91 | CHRM2 (1.00) | CHRM2NFKB1DNM1CA12CA1 | |
| SCHEMBL902505 | 0.91 | — | — | |
| SCHEMBL19941957 | 0.88 | CHRM2 (0.65) | CHRM2NFKB1DNM1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300010-B1 | PYRAZINE DERIVATIVES AS EPITHELIAL SODIUM CHANNEL BLOCKERS | NOVARTIS AG (CH) | 2015-03-04 | — | — | EP | disclosed |
| US-8236808-B2 | Pyrazine derivatives as ENAC blockers | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | disclosed |
| WO-2009150137-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-17 | — | — | WO | disclosed |