Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.71 |
| ▸ | CSNK2A2 | P19784 | 19/20 | 0.71 |
| ▸ | CSNK2B | P67870 | 19/20 | 0.71 |
| ▸ | PIM3 | Q86V86 | 18/20 | 0.71 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850345 | 0.87 | CSNK2A2 (0.76) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1855496 | 0.86 | PIM1 (0.89) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1852355 | 0.83 | PIM1 (0.80) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1854063 | 0.83 | PIM1 (1.00) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1852633 | 0.81 | CSNK2A2 (0.71) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1849631 | 0.81 | PIM1 (1.00) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1851595 | 0.81 | PIM1 (1.00) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1852531 | 0.80 | PIM1 (0.72) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL13650454 | 0.80 | PIM1 (0.68) | PIM1CSNK2A2CSNK2BPIM3PIM2 | |
| SCHEMBL1850401 | 0.80 | CSNK2A2 (1.00) | PIM1CSNK2A2CSNK2BPIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |