Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 17/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 9/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284321 | 0.89 | CACNA1B (0.60) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4282304 | 0.89 | CACNA1B (0.60) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4280044 | 0.88 | CACNA1B (0.53) | CACNA1BNR1I2CYP3A4KMT2A | |
| SCHEMBL8234436 | 0.85 | CACNA1B (0.56) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4284789 | 0.83 | CACNA1B (0.61) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4281393 | 0.81 | CACNA1B (0.59) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4277949 | 0.79 | CACNA1B (0.58) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4280160 | 0.79 | CACNA1B (0.58) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL4280158 | 0.79 | CACNA1B (0.58) | CACNA1BNR1I2CYP3A4 | |
| SCHEMBL13221467 | 0.79 | KMT2A (0.55) | CACNA1BNR1I2P2RX7CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000174-B2 | 4-phenylsulfonamidopiperidines as calcium channel blockers | PURDUE PHARMA L.P. (US) | 2015-04-07 | — | — | US | disclosed |
| EP-1814851-B1 | 4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS | EURO CELTIQUE SA (LU) | 2013-06-05 | — | — | EP | disclosed |
| US-20090105249-A1 | 4-phenylsulfonamidopiperidines as calcium channel blockers | EURO-CELTIQUE S.A. (LU) | 2009-04-23 | — | — | US | disclosed |
| EP-1814851-A2 | 4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006040181-A2 | 4-PHENYLSULFONAMIDOPIPERIDINES AS CALCIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105249-A1 | 4-phenylsulfonamidopiperidines as calcium channel blockers | CACNA1A, CACNA1E, CACNA1B | CACNA1B 3/4885NR1I2 1898/4885P2RX7 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.