Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.37 |
| ▸ | CHUK | O15111 | 3/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 4/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614895 | 0.83 | IKBKB (0.41) | IKBKBCHUKPRKD1PRKD2CDC7 | |
| SCHEMBL3616158 | 0.82 | IKBKB (0.47) | IKBKBCHUK | |
| SCHEMBL3612276 | 0.80 | MAP4K4 (0.49) | IKBKBCHUKPRKD1PRKD2CDC7 | |
| SCHEMBL3612278 | 0.80 | MAPKAPK2 (0.53) | PRKD1PRKD2CDC7MAPKAPK2PRKD3 | |
| SCHEMBL3618309 | 0.76 | JAK2 (0.49) | PRKD1PRKD2PRKD3 | |
| SCHEMBL3619274 | 0.76 | ACVR1 (0.43) | PRKD1PRKD2CDC7MAPKAPK2PRKD3 | |
| SCHEMBL3619357 | 0.75 | CCNC (0.48) | PRKD1PRKD2MAPKAPK2PRKD3 | |
| SCHEMBL3620099 | 0.75 | IKBKB (0.44) | IKBKBCHUKPRKD1PRKD2MAPKAPK2 | |
| SCHEMBL13408143 | 0.75 | CCNC (0.41) | PRKD1PRKD2MAPKAPK2 | |
| SCHEMBL3609047 | 0.74 | PRKD1 (0.50) | PRKD1PRKD2CDC7PRKD3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069333-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | Novartis Ag (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034600-A1 | PYRROLE DERIVATIVES USEFUL FOR THE TREATMENT OF CYTOKINE-MEDIATED DISEASES | NOVARTIS AG (CH) | 2008-03-27 | — | — | WO | disclosed |