Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Omeprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 3/20 | 0.43 |
| ▸ | ATP4B known ✓ | P51164 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | WDR5 | P61964 | 3/20 | 0.45 |
| ▸ | BRS3 | P32247 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 2/20 | 0.43 |
| ▸ | ATP1B1 | P05026 | 2/20 | 0.43 |
| ▸ | ATP1A3 | P13637 | 2/20 | 0.43 |
| ▸ | ATP1B2 | P14415 | 2/20 | 0.43 |
| ▸ | ATP1A2 | P50993 | 2/20 | 0.43 |
| ▸ | ATP1B3 | P54709 | 2/20 | 0.43 |
| ▸ | FXYD2 | P54710 | 2/20 | 0.43 |
| ▸ | ATP1A4 | Q13733 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Omeprazole SCHEMBL9242886 | 1.00 | CYP2C9 (0.45) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL28639206 | 0.92 | CYP2C9 (0.43) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL28038400 | 0.89 | CYP2C9 (0.51) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Esomeprazole SCHEMBL28017440 | 0.89 | CYP2C9 (0.51) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Esomeprazole SCHEMBL29673044 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL82985 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL30179968 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Esomeprazole SCHEMBL29350786 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL29538900 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A | |
| Omeprazole SCHEMBL1191 | 0.89 | BRS3 (0.52) | CYP2C9KMT2AWDR5BRS3ATP4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090068261-A1 | ORAL RAPID RELEASE PHARMACEUTICAL FORMULATION FOR PYRIDYLMETHYLSULFINYL-BENZIMIDAZOLES | MEPHA SCHWEIZ AG (CH) | 2009-03-12 | — | — | US | disclosed |