Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.76 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946976 | 0.87 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1POLBGAAMAPT | |
| SCHEMBL3942089 | 0.85 | HSP90AA1 (0.76) | HSP90AA1HSP90AB1POLBGAAMAPT | |
| SCHEMBL3945098 | 0.84 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1POLBGAAMAPT | |
| SCHEMBL4282884 | 0.81 | AGPAT2 (0.67) | HSP90AA1HSP90AB1AGPAT2KDM4E | |
| SCHEMBL4282163 | 0.81 | HSP90AA1 (0.54) | HSP90AA1HSP90AB1AGPAT2DYRK1AKDM4E | |
| SCHEMBL2849242 | 0.81 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1AGPAT2KDM4E | |
| SCHEMBL2850401 | 0.79 | BACE1 (0.52) | HSP90AA1HSP90AB1GAAMAPTSMN1; SMN2 | |
| SCHEMBL13880245 | 0.79 | AGPAT2 (0.79) | POLBGAAMAPTSMN1; SMN2AGPAT2 | |
| SCHEMBL4289224 | 0.79 | AGPAT2 (0.64) | HSP90AA1HSP90AB1MAPTAGPAT2ADCY10 | |
| SCHEMBL2849100 | 0.79 | AGPAT2 (0.64) | HSP90AA1HSP90AB1AGPAT2NPC1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | HSP90AA1 4126/4885HSP90AB1 4236/4885POLB 443/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | HSP90AA1 4006/4885HSP90AB1 3829/4885POLB 257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.