Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.48 |
| ▸ | GSK3A | P49840 | 6/20 | 0.48 |
| ▸ | PRKACA | P17612 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CDC7 | O00311 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.48 |
| ▸ | CDC42BPA | Q5VT25 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.48 |
| ▸ | PLK4 | O00444 | 4/20 | 0.48 |
| ▸ | PRKX | P51817 | 4/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.48 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4285256 | 0.89 | CDC7 (0.57) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL4291536 | 0.86 | CDC7 (0.54) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL27788225 | 0.86 | CLK4 (0.44) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL3669460 | 0.85 | CLK4 (0.49) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL3664505 | 0.83 | CDC7 (0.41) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL27788240 | 0.79 | CDC7 (0.55) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL3668504 | 0.73 | GSK3B (0.75) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL4289776 | 0.70 | CDC7 (0.57) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL3632690 | 0.69 | CDC7 (0.58) | CLK4GSK3APRKACACDK2CDC7 | |
| SCHEMBL3917675 | 0.69 | SRD5A2 (0.56) | CLK4GSK3AROCK1DAPK3CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-11-20 | — | — | US | disclosed |
| US-8648069-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343066-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | CLK4 260/4885GSK3A 2/4885PRKACA 178/4885 |
| US-20090203690-A1 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS | GSK3B, GSK3A, PIM3 | CLK4 260/4885GSK3A 2/4885PRKACA 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.