⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4294302 | 0.88 | — | — | |
| SCHEMBL7163200 | 0.80 | — | — | |
| SCHEMBL2928495 | 0.73 | — | — | |
| SCHEMBL28120796 | 0.68 | — | — | |
| SCHEMBL11301732 | 0.68 | — | — | |
| SCHEMBL11571443 | 0.66 | — | — | |
| SCHEMBL27352700 | 0.66 | — | — | |
| SCHEMBL28198396 | 0.66 | — | — | |
| SCHEMBL31634025 | 0.65 | — | — | |
| SCHEMBL4462509 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203770-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING Bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHISON CANCER RESEARCH CENTER (US) | 2009-08-13 | — | — | US | disclosed |
| US-7241804-B1 | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1218368-A4 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | HUTCHINSON FRED CANCER RES (US) | 2003-04-16 | — | — | EP | disclosed |
| EP-1218368-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | Fred Hutchinson Cancer Research Center (US) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001014365-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING bcl-2 FAMILY MEMBER PROTEINS | FRED HUTCHINSON CANCER RESEARCH CENTER (US) | 2001-03-01 | — | — | WO | disclosed |