Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.82 |
| ▸ | MEN1 | O00255 | 5/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | CASP1 | P29466 | 3/20 | 0.82 |
| ▸ | CASP7 | P55210 | 3/20 | 0.82 |
| ▸ | HBB | P68871 | 3/20 | 0.82 |
| ▸ | USP2 | O75604 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.82 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.82 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.82 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.82 |
| ▸ | TOP2A | P11388 | 1/20 | 0.82 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.82 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30884751 | 1.00 | TOP1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL28046515 | 0.94 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27477913 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3376452 | 0.93 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27781717 | 0.93 | TOP1 (0.84) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2423989 | 0.93 | TOP1 (0.84) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3377674 | 0.92 | TOP1 (0.82) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL23432496 | 0.91 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27595325 | 0.91 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27504832 | 0.91 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4389752-A1 | CAMPTOTHECIN DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | Simcere Zaiming Pharmaceutical Co., Ltd. (CN) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023020605-A1 | CAMPTOTHECIN DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 江苏先声药业有限公司 | 2023-02-23 | — | — | WO | disclosed |
| EP-4119582-A1 | COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER | Astellas Pharma Inc. (JP) | 2023-01-18 | — | — | EP | disclosed |
| EP-3725810-A1 | COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER | Astellas Pharma Inc. (JP) | 2020-10-21 | — | — | EP | disclosed |
| EP-3670537-A1 | THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER | Astellas Pharma Inc. (JP) | 2020-06-24 | — | — | EP | disclosed |
| WO-2011154574-A1 | CAMPTOTHECIN DERIVATIVES AS ANTITUMOURAL AGENTS | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (ES) | 2011-12-15 | — | — | WO | disclosed |
| US-20090285878-A1 | Compositions and methods for stabilizing liposomal drug formulations | TEKMIRA PHARMACEUTICALS CORPORATION (CA) | 2009-11-19 | — | — | US | disclosed |
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| EP-1807051-A2 | COMPOSITIONS AND METHODS FOR STABILIZING LIPOSOMAL CAMPTOTHECIN FORMULATIONS | Inex Pharmaceuticals Corporation (CA) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006052767-A2 | COMPOSITIONS AND METHODS FOR STABILIZING LIPOSOMAL CAMPTOTHECIN FORMULATIONS | INEX PHARMACEUTICALS CORPORATION (CA) | 2006-05-18 | — | — | WO | disclosed |
| EP-0802915-B1 | CAMPTOTHECIN DERIVATIVES AND ITS MANUFACTURING METHOD | CHONG KUN DANG CORP (KR) | 2002-12-04 | — | — | EP | disclosed |