Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 17/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 13/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | BRD2 | P25440 | 3/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290025 | 1.00 | AURKA (0.51) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL4297025 | 0.92 | JAK2 (0.51) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL4297021 | 0.92 | JAK2 (0.51) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1657589 | 0.91 | JAK2 (0.51) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1657593 | 0.91 | JAK2 (0.51) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1654979 | 0.89 | FGFR1 (0.48) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1654976 | 0.89 | FGFR1 (0.48) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL3402022 | 0.87 | FGFR1 (0.46) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1655318 | 0.87 | JAK2 (0.55) | AURKACDK4FGFR1FGFR2FGFR4 | |
| SCHEMBL1657652 | 0.86 | JAK2 (0.57) | AURKACDK4JAK2HDAC6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | claimed |
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | AURKA 755/4885CDK4 186/4885FGFR1 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.