Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.40 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4296007 | 0.86 | CHEK1 (0.68) | CHEK1 | |
| SCHEMBL4296686 | 0.79 | CHEK1 (0.73) | CHEK1POLB | |
| SCHEMBL4302533 | 0.79 | CHEK1 (0.73) | CHEK1 | |
| SCHEMBL13662594 | 0.79 | CHEK1 (0.39) | CHEK1 | |
| SCHEMBL5025815 | 0.78 | KDM4E (0.51) | CHEK1 | |
| SCHEMBL4291923 | 0.77 | CHEK1 (0.50) | CHEK1POLB | |
| SCHEMBL4288965 | 0.77 | CHEK1 (0.50) | CHEK1ACMSD | |
| SCHEMBL4300743 | 0.76 | CHEK1 (0.49) | CHEK1TBK1 | |
| SCHEMBL4294445 | 0.76 | CHEK1 (0.58) | CHEK1POLB | |
| SCHEMBL4287238 | 0.76 | CHEK1 (0.48) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885TBK1 118/4885IKBKE 169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.