Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 15/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCND2 | P30279 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284002 | 0.89 | RPS6KA3 (0.47) | RPS6KA3CDK4CCND1CDK2CCND2 | |
| SCHEMBL1657537 | 0.86 | AURKA (0.46) | PTK2RPS6KA3CDK4CDK2JAK2 | |
| SCHEMBL4290779 | 0.86 | RPS6KA3 (0.46) | PTK2RPS6KA3CDK4JAK2AURKA | |
| SCHEMBL4292753 | 0.84 | RPS6KA3 (0.54) | RPS6KA3CDK4CCND1JAK2AURKA | |
| SCHEMBL1657502 | 0.82 | RPS6KA3 (0.45) | RPS6KA3JAK2BRD4 | |
| SCHEMBL4288938 | 0.82 | RPS6KA3 (0.45) | RPS6KA3JAK2BRD4 | |
| SCHEMBL4293675 | 0.81 | JAK2 (0.43) | PTK2RPS6KA3CDK4JAK2AURKA | |
| SCHEMBL4286086 | 0.81 | RPS6KA3 (0.44) | RPS6KA3JAK2BRD4 | |
| SCHEMBL4283799 | 0.79 | SYK (0.43) | PTK2RPS6KA3CDK4JAK2AURKA | |
| SCHEMBL4288414 | 0.79 | JAK2 (0.45) | PTK2RPS6KA3CDK4JAK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | PTK2 175/4885RPS6KA3 303/4885CDK4 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.