Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.59 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4297135 | 0.92 | CHEK1 (0.56) | CHEK1NR4A2ROCK2 | |
| SCHEMBL4297838 | 0.90 | CHEK1 (0.56) | CHEK1NR4A2ROCK2 | |
| SCHEMBL4296990 | 0.88 | CHEK1 (0.65) | CHEK1NR4A2 | |
| SCHEMBL4300984 | 0.85 | CHEK1 (0.64) | CHEK1NR4A2 | |
| SCHEMBL4291211 | 0.85 | CHEK1 (0.59) | CHEK1CD274 | |
| SCHEMBL4295703 | 0.83 | CHEK1 (0.71) | CHEK1NR4A2 | |
| SCHEMBL4300340 | 0.82 | CHEK1 (0.69) | CHEK1NR4A2 | |
| SCHEMBL4294122 | 0.82 | CHEK1 (0.53) | CHEK1NR4A2ROCK2PDCD1CD274 | |
| SCHEMBL4294720 | 0.81 | CHEK1 (0.62) | CHEK1NR4A2 | |
| SCHEMBL4297134 | 0.81 | CHEK1 (0.57) | CHEK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258852-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, CDKN1A | CHEK1 1/4885NR4A2 2243/4885SMN1; SMN2 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.