Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.45 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.37 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL10722796 | 0.82 | SLC7A5 (0.49) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL4287332 | 0.81 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL21097842 | 0.81 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL1821153 | 0.81 | SLC7A5 (0.59) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL3490090 | 0.79 | SLC7A5 (0.54) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL27245949 | 0.79 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL4586624 | 0.79 | ALPI (0.57) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL9551454 | 0.79 | SLC7A5 (0.55) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL26977289 | 0.78 | SLC7A5 (0.60) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL16820323 | 0.78 | SLC7A5 (0.63) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090220997-A1 | Stimulating G Protein-Coupled Receptors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2009-09-03 | — | — | US | disclosed |
| WO-2007033233-A2 | STIMULATING G PROTEIN-COUPLED RECEPTORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-03-22 | — | — | WO | disclosed |