⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11084528 | 0.78 | POLB (0.35) | — | |
| SCHEMBL10863163 | 0.78 | CA12 (0.41) | — | |
| SCHEMBL27901185 | 0.75 | — | — | |
| SCHEMBL11085582 | 0.75 | TSHR (0.42) | — | |
| SCHEMBL11084808 | 0.72 | — | — | |
| SCHEMBL8795715 | 0.72 | ANPEP (0.49) | — | |
| SCHEMBL4396896 | 0.70 | HPGD (0.33) | — | |
| SCHEMBL3429214 | 0.70 | — | — | |
| SCHEMBL11062839 | 0.70 | HPGD (0.46) | — | |
| Hydrochloric Acid SCHEMBL4341709 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-56113778-A | — | — | None | — | — | JP | disclosed |
| EP-1463506-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| US-20090215770-A1 | Substituted Quinazoline Derivatives as Inhibitors of Aurora Kinases | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | US | disclosed |
| CN-100491372-C | Substituted quinazoline derivatives as inhibitors of aurora kinase | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| US-7402585-B2 | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2008-07-22 | — | — | US | disclosed |
| CN-1620296-A | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2005-05-25 | — | — | CN | disclosed |
| US-20050070561-A1 | Substituted quinazoline derivatives as inhibitors of aurora kinases | ASTRAZENECA AB (SE) | 2005-03-31 | — | — | US | disclosed |
| EP-1463506-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | Astrazeneca AB (SE) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003055491-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | disclosed |
| JP-S56113778-A | N- 1,3-DIOXOLAN-2-YLMETHYL AMINOETHANOL DERIVATIVE AND ITS PREPARATION | OTA SEIYAKU KK | 1981-09-07 | — | — | JP | disclosed |