Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 4/20 | 0.50 |
| ▸ | THRA | P10827 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4295206 | 1.00 | ESR1 (0.50) | ESR1THRATHRBALDH1A1HPGD | |
| Bromide SCHEMBL4295208 | 1.00 | ESR1 (0.50) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL862599 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL13475571 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL862816 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL13475563 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL14570401 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL15200209 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| SCHEMBL10039089 | 0.98 | ESR1 (0.51) | ESR1THRATHRBALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7064952 | 0.96 | ESR1 (0.50) | ESR1THRATHRBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090026942-A1 | Circuit substrate, electro-optical device and electronic appliances | SEIKO EPSON CORPORATION (JP) | 2009-01-29 | — | — | US | disclosed |
| US-20030214042-A1 | Circuit substrate, electro-optical device and electronic appliances | SEIKO EPSON CORPORATION (JP) | 2003-11-20 | — | — | US | disclosed |
| EP-1333497-A2 | Circuit substrate, electro-optical device and electronic appliances | SEIKO EPSON CORPORATION (JP) | 2003-08-06 | — | — | EP | disclosed |
| US-5821002-A | POLYARYLENEVINYLENE DERIVATIVES | SUMITOMO CHEMICAL COMPANY (JP) | 1998-10-13 | — | — | US | disclosed |
| EP-0725120-B1 | Polymeric fluorescent substance, production process thereof and organic electroluminescence device | SUMITOMO CHEMICAL CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| EP-0725120-A1 | Polymeric fluorescent substance, production process thereof and organic electroluminescence device | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-08-07 | — | — | EP | disclosed |