Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.48 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESRRG | P62508 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026383 | 1.00 | SPHK2 (0.48) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL3429334 | 0.94 | SPHK2 (0.49) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL3427378 | 0.94 | SPHK2 (0.49) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL3425937 | 0.94 | SPHK2 (0.49) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL3431942 | 0.85 | SPHK2 (0.47) | SPHK2SPHK1POLBL3MBTL1HRH3 | |
| SCHEMBL3427098 | 0.85 | SPHK2 (0.47) | SPHK2SPHK1POLBL3MBTL1HRH3 | |
| SCHEMBL3429567 | 0.85 | SPHK2 (0.47) | SPHK2SPHK1POLBL3MBTL1HRH3 | |
| SCHEMBL3085934 | 0.85 | SPHK1 (0.46) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL3085930 | 0.85 | SPHK1 (0.46) | SPHK2SPHK1ADRA1DADRA1AADRA1B | |
| SCHEMBL4026380 | 0.85 | SPHK1 (0.46) | SPHK2SPHK1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463506-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF AURORA KINASES | ASTRAZENECA AB (SE) | 2009-10-21 | — | — | EP | disclosed |
| US-20090215770-A1 | Substituted Quinazoline Derivatives as Inhibitors of Aurora Kinases | ASTRAZENECA AB (SE) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215770-A1 | Substituted Quinazoline Derivatives as Inhibitors of Aurora Kinases | AURKC, AURKA, AURKB | SPHK2 815/4885SPHK1 776/4885ADRA1D 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.