Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 12/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4295881 | 1.00 | GRIA4 (0.46) | GRIA4CA1CA2GRIA1TRPV1 | |
| SCHEMBL6561639 | 0.92 | GRIA4 (0.51) | GRIA4CA1CA2GRIA1CA12 | |
| SCHEMBL3711628 | 0.88 | GRIA4 (0.48) | GRIA4CA1CA2GRIA1 | |
| SCHEMBL13255710 | 0.88 | GRIA4 (0.48) | GRIA4CA1CA2GRIA1 | |
| SCHEMBL5186065 | 0.82 | GRIA4 (0.43) | GRIA4CA1CA2 | |
| SCHEMBL5186189 | 0.82 | GRIA4 (0.54) | GRIA4GRIA1 | |
| SCHEMBL5769048 | 0.82 | GRIA4 (0.42) | GRIA4CA1CA2GRIA1CA12 | |
| SCHEMBL3703932 | 0.82 | CYP2C19 (0.47) | GRIA4CA1CA2GRIA1 | |
| SCHEMBL3703930 | 0.82 | CYP2C19 (0.47) | GRIA4CA1CA2GRIA1 | |
| SCHEMBL13663202 | 0.81 | GRIA4 (0.43) | GRIA4CA1CA2GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010087982-A1 | GLUR2 RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2010-08-05 | — | — | WO | disclosed |
| US-20090270508-A1 | GluR2 receptor modulators | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-10-29 | — | — | US | disclosed |
| US-20090270508-A1 | GluR2 receptor modulators | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270508-A1 | GluR2 receptor modulators | GRM2, GRIK2, GRIN2A | GRIA4 16/4885CA1 1934/4885CA2 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.