⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22792550 | 0.76 | — | — | |
| SCHEMBL7244889 | 0.76 | CA12 (0.38) | — | |
| SCHEMBL27554893 | 0.74 | — | — | |
| SCHEMBL24433147 | 0.69 | — | — | |
| SCHEMBL130624 | 0.64 | — | — | |
| SCHEMBL6485845 | 0.63 | — | — | |
| SCHEMBL27530105 | 0.62 | — | — | |
| SCHEMBL6486144 | 0.61 | — | — | |
| SCHEMBL4242766 | 0.60 | CHRM2 (0.48) | — | |
| SCHEMBL15075 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117126846-A | Oligonucleotide conjugates | 罗氏创新中心哥本哈根有限公司 | 2023-11-28 | — | — | CN | disclosed |
| US-11155816-B2 | Oligonucleotide conjugates | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2021-10-26 | — | — | US | disclosed |
| US-10358643-B2 | Poly oligomer compound with biocleavable conjugates | HOFFMANN-LA ROCHE, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| EP-3406718-A1 | OLIGONUCLEOTIDE CONJUGATES | Roche Innovation Center Copenhagen A/S (DK) | 2018-11-28 | — | — | EP | disclosed |
| US-10077443-B2 | Oligonucleotide conjugates | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-09-18 | — | — | US | disclosed |
| US-20180251764-A1 | Oligonucleotide Conjugates | ROCHE INNOVATION CENTER COPENHAGEN A/S (CH) | 2018-09-06 | — | — | US | disclosed |
| US-20170349896-A1 | POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2017-12-07 | — | — | US | disclosed |
| EP-3099797-A1 | POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES | F. Hoffmann-La Roche AG (CH) | 2016-12-07 | — | — | EP | disclosed |
| US-20150275212-A1 | Oligonucleotide Conjugates | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2015-10-01 | — | — | US | disclosed |
| EP-2920304-A1 | OLIGONUCLEOTIDE CONJUGATES | Roche Innovation Center Copenhagen A/S (DK) | 2015-09-23 | — | — | EP | disclosed |
| WO-2015113922-A1 | POLY OLIGOMER COMPOUND WITH BIOCLEAVABLE CONJUGATES | ROCHE INNOVATION CENTER COPENHAGEN A/S (DK) | 2015-08-06 | — | — | WO | disclosed |
| WO-2014076195-A1 | OLIGONUCLEOTIDE CONJUGATES | SANTARIS PHARMA A/S (DK) | 2014-05-22 | — | — | WO | disclosed |
| US-20090203132-A1 | PYRROLIDINYL GROUPS FOR ATTACHING CONJUGATES TO OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. | 2009-08-13 | — | — | US | disclosed |
| US-20080199960-A1 | Methods for the Delivery of Oligomeric Compounds | K.U. LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2008-08-21 | — | — | US | disclosed |
| WO-2006031461-A2 | PYRROLIDINYL GROUPS FOR ATTACHING CONJUGATES TO OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2006-03-23 | — | — | WO | disclosed |
| WO-2005113571-A2 | METHODS FOR THE DELIVERY OF OLIGOMERIC COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-12-01 | — | — | WO | disclosed |
| WO-2004044141-A2 | CONJUGATED OLIGOMERIC COMPOUNDS AND THEIR USE IN GENE MODULATION | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-27 | — | — | WO | disclosed |