Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 18/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 17/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 15/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 15/20 | 0.68 |
| ▸ | PRKD2 | Q9BZL6 | 13/20 | 0.68 |
| ▸ | MINK1 | Q8N4C8 | 13/20 | 0.68 |
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 10/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 5/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.49 |
| ▸ | TAOK1 | Q7L7X3 | 8/20 | 0.49 |
| ▸ | GSK3B | P49841 | 8/20 | 0.49 |
| ▸ | CSNK1G3 | Q9Y6M4 | 7/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 6/20 | 0.49 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299237 | 0.81 | MAP4K4 (0.71) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4300444 | 0.81 | MAP4K4 (1.00) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4308498 | 0.80 | MAP4K4 (0.70) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4300766 | 0.77 | MAP4K4 (0.63) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL9056922 | 0.77 | MAP4K4 (0.64) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4304066 | 0.75 | CSNK1D (1.00) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4293934 | 0.75 | MAP4K4 (0.55) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4300842 | 0.74 | MAP4K4 (0.64) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4303988 | 0.74 | CSNK1D (0.95) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 | |
| SCHEMBL4303973 | 0.73 | MAP4K4 (0.58) | CSNK1DMAP4K4MAPK9PRKD3PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188083-B2 | Triazolopyridazines | ABBOTT LABORATORIES (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090270402-A1 | Novel triazolopyridazines | ABBVIE INC. | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270402-A1 | Novel triazolopyridazines | MAP3K5, MAP3K1, MAP3K2 | CSNK1D 173/4885MAP4K4 24/4885MAPK9 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.