SCHEMBL4297455

SCHEMBL4297455

N=C(N)c1ccc([C@@H](NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PLAU P00749 10/20 1.00
PLG P00747 4/20 1.00
KLK8 O60259 3/20 1.00
F2 P00734 3/20 1.00
F10 P00742 3/20 1.00
PLAT P00750 3/20 1.00
KLK4 Q9Y5K2 3/20 1.00
KLK1 P06870 3/20 0.76
TP53 P04637 1/20 0.73
KLK2 P20151 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4295336 1.00 PLAU (1.00) PLAUPLGKLK8F2F10
Hydrochloric Acid SCHEMBL7390446 0.99 PLAU (0.98) PLAUPLGKLK8F2F10
Hydrochloric Acid SCHEMBL7393506 0.93 PLAU (0.87) PLAUPLGKLK8F2F10
Hydrochloric Acid SCHEMBL7386655 0.92 PLAU (0.85) PLAUPLGKLK8F2F10
SCHEMBL1364942 0.91 PLAU (0.83) PLAUPLGKLK8F2F10
Hydrochloric Acid SCHEMBL7390732 0.90 PLAU (0.81) PLAUPLGKLK8F2F10
SCHEMBL17126717 0.88 PLAU (0.78) PLAUPLGKLK8F2F10
SCHEMBL2240660 0.87 PLAU (0.77) PLAUPLGKLK8F2F10
SCHEMBL17126245 0.87 KLK1 (0.83) PLAUPLGKLK8F2F10
Hydrochloric Acid SCHEMBL7387935 0.86 PLAU (0.75) PLAUPLGKLK8F2F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090297534-A1 Catalytic Immunoglobulins BBK32 and Uses Therefor PAUL SUDHIR 2009-12-03 US disclosed