Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | GSK3A | P49840 | 1/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.53 |
| ▸ | STK3 | Q13188 | 1/20 | 0.53 |
| ▸ | STK11 | Q15831 | 1/20 | 0.53 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116485 | 0.89 | AAK1 (0.60) | GSK3BGSK3AAAK1AXLTNIK | |
| SCHEMBL4302089 | 0.87 | GSK3B (0.60) | GSK3BGSK3AAAK1GAKSTK16 | |
| SCHEMBL7117296 | 0.84 | AAK1 (0.65) | GSK3BGSK3AAAK1AXLKIT | |
| SCHEMBL7114155 | 0.84 | GSK3A (0.62) | GSK3BGSK3AAAK1AXLKIT | |
| SCHEMBL7117585 | 0.83 | AXL (0.61) | GSK3BGSK3AAAK1PIM1AXL | |
| SCHEMBL7051030 | 0.83 | ADORA1 (0.53) | GSK3BGSK3AAAK1 | |
| SCHEMBL4308629 | 0.83 | KIT (0.57) | GSK3BGSK3AAAK1DYRK1ANTRK1 | |
| SCHEMBL7117475 | 0.83 | AAK1 (0.62) | GSK3BGSK3AAAK1GAKSTK16 | |
| SCHEMBL7118114 | 0.83 | DYRK1A (0.56) | GSK3BGSK3AAAK1DYRK1A | |
| SCHEMBL7116630 | 0.83 | AAK1 (0.56) | GSK3BGSK3AAAK1PIM1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| US-20090306126-A1 | Indole Derivatives | ASTRAZENECA AB (SE) | 2009-12-10 | — | — | US | disclosed |
| CN-101448827-A | Indole derivatives | ASTRAZENECA AB (SE) | 2009-06-03 | — | — | CN | disclosed |
| WO-2003028724-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306126-A1 | Indole Derivatives | MTOR, IDO1, AKT1S1 | GSK3B 18/4885GSK3A 23/4885AAK1 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.