Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 8/20 | 0.64 |
| ▸ | KHK | P50053 | 1/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.62 |
| ▸ | STK3 | Q13188 | 3/20 | 0.62 |
| ▸ | CDC7 | O00311 | 1/20 | 0.62 |
| ▸ | ROS1 | P08922 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | MARK3 | P27448 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | CDK8 | P49336 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.62 |
| ▸ | MELK | Q14680 | 1/20 | 0.62 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.62 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.62 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.62 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.62 |
| ▸ | STK4 | Q13043 | 2/20 | 0.54 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18967255 | 0.86 | STK4 (0.70) | AKT1LRRK2STK3STK4 | |
| SCHEMBL9966954 | 0.84 | AKT1 (0.85) | AKT1KHKKITLIMK2 | |
| SCHEMBL3955185 | 0.83 | LRRK2 (0.63) | AKT1LRRK2STK3CDC7ROS1 | |
| Hydrochloric Acid SCHEMBL15456486 | 0.82 | AKT1 (0.82) | AKT1KHKKITLIMK2 | |
| Hydrochloric Acid SCHEMBL21979540 | 0.82 | AKT1 (0.82) | AKT1KHKKITLIMK2 | |
| SCHEMBL3960587 | 0.82 | STK3 (0.80) | LRRK2STK3CDC7ROS1KIT | |
| SCHEMBL18967632 | 0.82 | KHK (0.71) | AKT1KHKLRRK2JAK3 | |
| SCHEMBL9967041 | 0.81 | AKT1 (0.68) | AKT1KHKLRRK2STK3STK4 | |
| SCHEMBL3536069 | 0.81 | AKT1 (0.69) | AKT1LRRK2STK3CDC7ROS1 | |
| SCHEMBL3536255 | 0.81 | LRRK2 (0.58) | AKT1KHKLRRK2STK3CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450332-B2 | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20120329818-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2012-12-27 | — | — | US | disclosed |
| US-8193202-B2 | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090264450-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329818-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LIMK2, LIMK1, LIMA1 | AKT1 156/4885KHK 1580/4885LRRK2 145/4885 |
| US-20090264450-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LIMK2, LIMK1, LIMA1 | AKT1 156/4885KHK 1580/4885LRRK2 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.