Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.60 |
| ▸ | CSF1R | P07333 | 11/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4928534 | 0.89 | PDE4B (0.59) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL4298665 | 0.88 | PDE4B (0.58) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL4306760 | 0.87 | PDE4B (0.67) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL4924230 | 0.87 | PDE4B (0.57) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL4299487 | 0.86 | PDE4B (0.59) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL4928787 | 0.84 | PDE4B (0.55) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL8305998 | 0.84 | PDE4B (0.59) | PDE4BCSF1RMTNR1B | |
| SCHEMBL4928496 | 0.83 | PDE4B (0.54) | PDE4BCSF1RMTNR1BCYP3A4CYP2C9 | |
| SCHEMBL4928653 | 0.83 | PDE4B (0.54) | PDE4BCSF1RMTNR1BBRD4BRD2 | |
| SCHEMBL31020770 | 0.83 | PDE4B (0.61) | PDE4BCSF1RMTNR1BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270444-A1 | 1,7-Naphthyridines | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20090270444-A1 | 1,7-Naphthyridines | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | GLAXO GROUP LIMITED | 2008-06-19 | — | — | US | disclosed |
| EP-1812434-A2 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006097340-A1 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006053784-A2 | 1,7-NAPHTHYRIDINES AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146563-A1 | 1,7-Naphthyridines as Pde4 Inhibitors | PDE4A, PDE3B, PDE4B | PDE4B 3/4885CSF1R 4095/4885MTNR1B 694/4885 |
| US-20090270444-A1 | 1,7-Naphthyridines | CYP2F1, CYP2S1, CYP1A1 | PDE4B 2570/4885CSF1R 2695/4885MTNR1B 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.