Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.66 |
| ▸ | PRKCG | P05129 | 2/20 | 0.66 |
| ▸ | PRKACA | P17612 | 2/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.66 |
| ▸ | AKT1 | P31749 | 2/20 | 0.66 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.66 |
| ▸ | CLK2 | P49760 | 2/20 | 0.66 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.66 |
| ▸ | PRKX | P51817 | 2/20 | 0.66 |
| ▸ | NEK4 | P51957 | 2/20 | 0.66 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.66 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.66 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.66 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.66 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.66 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286537 | 0.80 | CLK4 (1.00) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4292230 | 0.80 | ROCK1 (0.84) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4282293 | 0.80 | ROCK1 (0.84) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4286997 | 0.80 | ROCK1 (0.84) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4291559 | 0.78 | ROCK1 (1.00) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4283685 | 0.78 | MAP4K4 (0.78) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4286942 | 0.78 | MAP4K4 (0.67) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4284779 | 0.78 | MAP4K4 (0.67) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4280390 | 0.77 | MAP4K4 (0.66) | MAP4K4PRKCGPRKACARPS6KB1AKT1 | |
| SCHEMBL4280545 | 0.77 | ROCK1 (0.77) | MAP4K4PRKCGPRKACARPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009126635-A1 | 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | WO | disclosed |