Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL273981 | 0.90 | NR1H4 (0.82) | NR1H4MAPT | |
| SCHEMBL4303273 | 0.89 | NR1H4 (0.64) | NR1H4ABCG2 | |
| SCHEMBL4303367 | 0.89 | NR1H4 (0.64) | NR1H4ABCB1ABCG2 | |
| SCHEMBL4305536 | 0.87 | NR1H4 (0.78) | NR1H4ABCB1ABCG2MAPT | |
| SCHEMBL4298714 | 0.84 | NR1H4 (0.66) | NR1H4ABCB1ABCG2 | |
| SCHEMBL4305806 | 0.82 | NR1H4 (0.48) | NR1H4MAPT | |
| SCHEMBL275111 | 0.80 | NR1H4 (1.00) | NR1H4ABCB1ABCG2MAPT | |
| SCHEMBL273221 | 0.80 | NR1H4 (0.82) | NR1H4MAPT | |
| SCHEMBL274733 | 0.80 | NR1H4 (0.82) | NR1H4MAPT | |
| SCHEMBL4300482 | 0.78 | NR1H4 (0.78) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595311-B2 | Modulating active of receptors; therapy prevention of disease such aas symthrome X, antidiabetic agents, insulin resistance, hypoglycemic agents | EXELIXIS, INC. (US) | 2009-09-29 | — | — | US | claimed |